Relative bioavailability of pediatric oral solution and tablet formulations of trametinib in adult patients with solid tumors

Author:

Cox Donna S.1,Allred Alicia1,Zhou YanYan1,Infante Jeffrey R.2,Gordon Michael S.3,Bendell Johanna2,Jones Suzanne2,Burris Howard2,Orford Keith1

Affiliation:

1. GlaxoSmithKline; Collegeville PA USA

2. Sarah Cannon Research Institute; Nashville TN USA

3. Pinnacle Oncology Hematology; Scottsdale AZ USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science

Reference7 articles.

1. Relative bioavailability of liquid and tablet formulations of the antiparasitic moxidectin;Korth-Bradley;Clin Pharm Drug Dev.,2012

2. Guidance for Industry: Bioavailability and Bioequivalence Studies for Orally Administered Drug Products-General Considerations, US Department of Health and Human Services, FDA, Center for Drug Evaluation and Research (CDER); December 2002

3. Evaluation of the effects of food on the single-dose pharmacokinetics of trametinib, a first-in-class MEK inhibitor, in patients with cancer;Cox;J Clin Pharmacol.,2013

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