PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition

Author:

Zhou Wei1,Jubb Adrian M2,Lyle Karen2,Xiao Qian3,Ong Christy C1,Desai Rupal4,Fu Ling4,Gnad Florian5,Song Qinghua6,Haverty Peter M5,Aust Daniela7,Grützmann Robert8,Romero Mally1,Totpal Klara1,Neve Richard M9,Yan Yibing4,Forrest William F6,Wang Yulei4,Raja Rajiv4,Pilarsky Christian8,de Jesus-Acosta Ana3,Belvin Marcia1,Friedman Lori S1,Merchant Mark1ORCID,Jaffee Elizabeth M3,Zheng Lei3,Koeppen Hartmut2,Hoeflich Klaus P1

Affiliation:

1. Department of Translational Oncology; Genentech, Inc; South San Francisco CA 94080 USA

2. Department of Pathology; Genentech, Inc; South San Francisco CA 94080 USA

3. The Sidney Kimmel Comprehensive Cancer Center; Johns Hopkins University School of Medicine; Baltimore MD 21231 USA

4. Department of Oncology Biomarker Development; Genentech, Inc; South San Francisco CA 94080 USA

5. Department of Bioinformatics and Computational Biology; Genentech, Inc; South San Francisco CA 94080 USA

6. Department of Biostatics; Genentech, Inc; South San Francisco CA 94080 USA

7. Department of Pathology; University Hospital Dresden; Fetscherstrasse 74 01307 Dresden Germany

8. Department of Surgery; University Hospital Dresden; Fetscherstrasse 74 01307 Dresden Germany

9. Department of Molecular Diagnostics and Cancer Cell Biology; Genentech, Inc; South San Francisco CA 94080 USA

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Reference50 articles.

1. Cancer Facts & Figures 2013 American Cancer Society http://www.cancer.org/research/cancerfactsstatistics/cancerfactsfigures2013/index

2. Pancreatic cancer;Vincent;Lancet,2011

3. Pancreatic cancer;Hidalgo;N Engl J Med,2010

4. New tools and novel approaches in treating locally advanced pancreatic adenocarcinoma;Ahmed;JOP,2012

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