Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors

Author:

Rudolph Anja1,Milne Roger L.23,Truong Thérèse45,Knight Julia A.67,Seibold Petra1,Flesch-Janys Dieter89,Behrens Sabine1,Eilber Ursula1,Bolla Manjeet K.10,Wang Qin10,Dennis Joe10,Dunning Alison M.11,Shah Mitul11,Munday Hannah R.11,Darabi Hatef12,Eriksson Mikael12,Brand Judith S.12,Olson Janet13,Vachon Celine M.13,Hallberg Emily13,Castelao J. Esteban14,Carracedo Angel151617,Torres Maria16,Li Jingmei18,Humphreys Keith12,Cordina-Duverger Emilie45,Menegaux Florence45,Flyger Henrik19,Nordestgaard Børge G.2021,Nielsen Sune F.2021,Yesilyurt Betul T.22,Floris Giuseppe23,Leunen Karin23,Engelhardt Ellen G.24,Broeks Annegien25,Rutgers Emiel J.26,Glendon Gord27,Mulligan Anna Marie2829,Cross Simon30,Reed Malcolm31,Gonzalez-Neira Anna32,Arias Perez José Ignacio33,Provenzano Elena3435,Apicella Carmel36,Southey Melissa C.37,Spurdle Amanda38,Häberle Lothar39,Beckmann Matthias W.39,Ekici Arif B.40,Dieffenbach Aida Karina4142,Arndt Volker41,Stegmaier Christa43,McLean Catriona44,Baglietto Laura23,Chanock Stephen J.45,Lissowska Jolanta46,Sherman Mark E.4547,Brüning Thomas48,Hamann Ute49,Ko Yon-Dschun50,Orr Nick51,Schoemaker Minouk52,Ashworth Alan51,Kosma Veli-Matti5354,Kataja Vesa555657,Hartikainen Jaana M.5354,Mannermaa Arto5354,Swerdlow Anthony5258,Giles Graham G.23,Brenner Hermann4142,Fasching Peter A.3959,Chenevix-Trench Georgia38,Hopper John36,Benítez Javier60,Cox Angela31,Andrulis Irene L.2761,Lambrechts Diether22,Gago-Dominguez Manuela15,Couch Fergus62,Czene Kamila12,Bojesen Stig E.2021,Easton Doug F.1011,Schmidt Marjanka K.63,Guénel Pascal45,Hall Per12,Pharoah Paul D. P.1110,Garcia-Closas Montserrat5264,Chang-Claude Jenny1, , ,

Affiliation:

1. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ); Heidelberg Germany

2. Cancer Epidemiology Centre, Cancer Council Victoria; Melbourne Vic Australia

3. Centre for Epidemiology & Biostatistics, Melbourne School of Population and Global Health; The University of Melbourne; Vic Australia

4. Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer; Villejuif France

5. Unité Mixte de Recherche Scientifique (UMRS) 1018; University Paris-Sud; Villejuif France

6. Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Toronto ON Canada

7. Division of Epidemiology, Dalla Lana School of Public Health; University of Toronto; ON Canada

8. Department of Cancer Epidemiology/Clinical Cancer Registry; University Clinic Hamburg-Eppendorf; Hamburg Germany

9. Institute for Medical Biometrics and Epidemiology; University Clinic Hamburg-Eppendorf; Hamburg Germany

10. Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology; University of Cambridge; United Kingdom

11. Department of Oncology, Centre for Cancer Genetic Epidemiology; University of Cambridge; United Kingdom

12. Department of Medical Epidemiology and Biostatistics; Karolinska Institutet; Stockholm Sweden

13. Department of Health Sciences Research; Mayo Clinic; Rochester MN

14. Oncology and Genetics Unit, Biomedical Research Institute of Vigo (IBIV), Complejo Hospitalario; Universitario de Vigo, Servicio Galego de Saude (SERGAS); Vigo Spain

15. Genomic Medicine Group, Galician Foundation of Genomic Medicine, Servicio Galego de Saude (SERGAS); Instituto de Investigación Sanitaria de Santiago (IDIS); Santiago de Compostela Spain

16. National Genotyping Center-Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER); University of Santiago de Compostela; Galicia Spain

17. Center of Excellence in Genomic Medicine Research; King Abdulaziz University; Jeddah Kingdom of Saudi Arabia

18. Human Genetics Division, Genome Institute of Singapore

19. Department of Breast Surgery, Herlev Hospital; Copenhagen University Hospital; Copenhagen Denmark

20. Copenhagen General Population Study, Herlev Hospital; Copenhagen University Hospital, University of Copenhagen; Denmark

21. Department of Clinical Biochemistry, Herlev Hospital; Copenhagen University Hospital, University of Copenhagen; Denmark

22. Vesalius Research Center (VRC), VIB; Leuven Belgium

23. Multidisciplinary Breast Center; University Hospital Gasthuisberg; Leuven Belgium

24. Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital; Amsterdam The Netherlands

25. Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital; Amsterdam The Netherlands

26. Department of Surgery; Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital; Amsterdam The Netherlands

27. Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital; Toronto ON Canada

28. Laboratory Medicine Program; University Health Network; Toronto ON Canada

29. Department of Laboratory Medicine and Pathobiology; University of Toronto; ON Canada

30. Academic Unit of Pathology, Department of Neuroscience; University of Sheffield; United Kingdom

31. Sheffield Cancer Research Centre, Department of Oncology; University of Sheffield; United Kingdom

32. Human Genotyping Unit-CEGEN, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO); Madrid Spain

33. Servicio de Cirugía General y Especialidades, Hospital Monte Naranco; Oviedo Spain

34. Cancer Research UK Cambridge Institute; Cambridge United Kingdom

35. Cambridge Breast Unit, Addenbrooke's Hospital; Cambridge University Hospital NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre; Cambridge United Kingdom

36. Centre for Molecular, Environmental, Genetic and Analytic Epidemiology; University of Melbourne; Vic Australia

37. Department of Pathology; University of Melbourne; Vic Australia

38. Department of Genetics; QIMR Berghofer Medical Research Institute; Brisbane Qld Australia

39. Department of Gynecology and Obstetrics; University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN; Erlangen Germany

40. Institute of Human Genetics; University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN; Erlangen Germany

41. Division of Clinical Epidemiology and Aging Research; German Cancer Research Center (DKFZ); Heidelberg Germany

42. German Cancer Consortium (DKTK); Heidelberg Germany

43. Saarland Cancer Registry; Saarbrücken Germany

44. Anatomical Pathology, The Alfred Hospital; Melbourne Vic Australia

45. Division of Cancer Epidemiology and Genetics, National Cancer Institute; Bethesda MD

46. Department of Cancer Epidemiology and Prevention; M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology; Warsaw Poland

47. Division of Cancer Prevention, National Cancer Institute; Bethesda MD

48. Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA); Bochum Germany

49. Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ); Heidelberg Germany

50. Department of Internal Medicine; Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus; Bonn Germany

51. Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research; London United Kingdom

52. Division of Genetics and Epidemiology, Institute of Cancer Research; Sutton Surrey United Kingdom

53. School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland; University of Eastern Finland; Kuopio Finland

54. Imaging Center, Department of Clinical Pathology; Kuopio University Hospital; Kuopio Finland

55. School of Medicine, Institute of Clinical Medicine, Oncology and Cancer Center of Eastern Finland; University of Eastern Finland; Kuopio Finland

56. Cancer Center; Kuopio University Hospital; Kuopio Finland

57. Jyväskylä Central Hospital; Jyväskylä Finland

58. Division of Breast Cancer Research, Institute of Cancer Research; Sutton Surrey United Kingdom

59. Division of Hematology-Oncology, Department of Medicine; David Geffen School of Medicine, University of California; Los Angeles Los Angeles, CA

60. Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research, Centre (CNIO); Madrid Spain

61. Department of Molecular Genetics; University of Toronto; ON Canada

62. Department of Laboratory Medicine and Pathology; Mayo Clinic; Rochester MN

63. Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital; Amsterdam The Netherlands

64. Division of Breast Cancer Research, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research; London United Kingdom

Funder

European Commission

Publisher

Wiley

Subject

Cancer Research,Oncology

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