Gut Hormone Profiles in Critically Ill Neonates on Extracorporeal Membrane Oxygenation

Abstract

ABSTRACTObjectives:The objective of this study was to gain insight into the hormonal responses to enteral nutrition in critically ill newborns requiring venoarterial extracorporeal membrane oxygenation (ECMO) by analyzing plasma gut hormone levels of gastrin, cholecystokinin and peptide‐YY in relation to enteral nutrition.Methods:In 24 consecutive neonates treated with venoarterial ECMO intestinal hormone secretions were determined by radioimmunoassay at 2‐day intervals. Twelve received parenteral nutrition only. In 12 enteral nutrition was introduced later. The findings in these patients were compared with those of 16 measurements in eight non‐ECMO treated age‐matched controls. Mixed model analysis of variance was used for statistical analysis.Results:Concentrations of gastrin, cholecystokinin and peptide‐YY were significantly higher in ECMO patients receiving enteral nutrition compared with ECMO patients who received parenteral nutrition (62, 3.8 and 59.4 pmol/L versus 46, 3.1 and 34.7 pmol/L, respectively). Overall, plasma hormone levels did not differ from those in age‐matched controls.Conclusions:Intestinal hormone levels showed normal responses after introduction of enteral feeding, comparable with those in age‐matched controls without ECMO. These results do not provide an argument for withholding enteral nutrition even in the most severely ill neonates on venoarterial ECMO.