Optimal seamless phase 2/3 oncology trial designs based on Probability of Success (PoS)
Author:
Affiliation:
1. Takeda Pharmaceuticals; Cambridge Massachusetts
2. Department of Biostatistics; Harvard University; Boston Massachusetts
3. Nektar Therapeutics; San Francisco California
Publisher
Wiley
Subject
Statistics and Probability,Epidemiology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/sim.7910/fullpdf
Reference23 articles.
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3. Combining different phases in the development of medical treatments within a single trial;Bauer;Statist Med,1999
4. Testing and estimation in flexible group sequential designs with adaptive treatment selection;Posch;Statist Med,2005
5. Confirmatory seamless phase II/III clinical trials with hypotheses selection at interim: general concepts;Bretz;Biom J,2006
Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Master Protocols for Precision Medicine in Oncology: Overcoming Methodology of Randomized Clinical Trials;Life;2021-11-17
2. Seamless phase 2/3 oncology trial design with flexible sample size determination;Statistics in Medicine;2020-04-27
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