Cytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets

Author:

Kirchmeyer Mélanie1,Servais Florence A.1,Hamdorf Matthias1,Nazarov Petr V.2,Ginolhac Aurélien3,Halder Rashi4,Vallar Laurent2,Glanemann Matthias5,Rubie Claudia5,Lammert Frank6,Kreis Stephanie1,Behrmann Iris1

Affiliation:

1. Signal Transduction Laboratory; Life Sciences Research Unit; University of Luxembourg; 6 Avenue du Swing 4367 Belvaux Luxembourg

2. Proteome and Genome Research Unit; Department of Oncology; Luxembourg Institute of Health; 1A-B rue Thomas Edison 1445 Strassen Luxembourg

3. Bioinformatics Core; Life Sciences Research Unit; University of Luxembourg; 6 Avenue du Swing 4367 Belvaux Luxembourg

4. Luxembourg Centre for Systems Biomedicine; University of Luxembourg; 7 Avenue des Hauts Fourneaux 4362 Esch-sur-Alzette Luxembourg

5. Department of Surgery; Saarland University Medical Center; Kirrberger Straße 100 Homburg Germany

6. Department of Medicine II; Saarland University Medical Center; Kirrberger Straße 100 Homburg Germany

Funder

Fonds National de la Recherche Luxembourg

Deutsche Forschungsgemeinschaft

Université du Luxembourg

Publisher

Wiley

Subject

Cell Biology,Immunology,Immunology and Allergy

Reference78 articles.

1. Hepatocellular carcinoma;Llovet;Nat Rev Dis Primers,2016

2. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma;European Association for the Study of the Liver;J Hepatol,2012

3. Howlader N Noone AM Krapcho M SEER Cancer Statistics Review, 1975-2014 Bethesda, MD National Cancer Institute 2017.

4. Interleukin-6: designing specific therapeutics for a complex cytokine;Garbers;Nature Rev Drug Disc,2018

5. Interleukin-6 signaling pathway in targeted therapy for cancer;Guo;Cancer Treat Rev,2012

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