A stable engineered human IgG3 antibody with decreased aggregation during antibody expression and low pH stress-Reference-Cited by-同舟云学术

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A stable engineered human IgG3 antibody with decreased aggregation during antibody expression and low pH stress

Published:2019-03-22 Issue:5 Volume:28 Page:900-909
ISSN:0961-8368
Container-title:Protein Science
language:en
Short-container-title:Protein Science

Author:

Saito Seiji¹,Namisaki Hiroshi²,Hiraishi Keiko¹,Takahashi Nobuaki³,Iida Shigeru¹

Affiliation:

1. Antibody & Biologics Research Laboratories, R&D DivisionKyowa Hakko Kirin Co., Ltd. Tokyo, 194‐8533 Japan

2. Open Innovation Department, R&D DivisionKyowa Hakko Kirin Co., Ltd. Tokyo, 194‐8533 Japan

3. Research Functions Unit, R&D DivisionKyowa Hakko Kirin Co., Ltd. Tokyo, 194‐8533 Japan

Publisher

Wiley

Subject

Molecular Biology,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/pro.3598

Reference43 articles.

1. Antibodies to watch in 2018

2. Isotype selection in antibody engineering

3. IgG Subclasses and Allotypes: From Structure to Effector Functions

4. Immunoglobulin G3 from Polyclonal Human Immunodeficiency Virus (HIV) Immune Globulin Is More Potent than Other Subclasses in Neutralizing HIV Type 1

5. Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases

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3. The hinge-engineered IgG1-IgG3 hybrid subclass IgGh47 potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodies;Nature Communications;2024-04-27

4. The increased hinge flexibility of an IgG1-IgG3 hybrid monoclonal enhances Fc-mediated protection against group A streptococci;2023-10-18

5. Understanding and controlling the molecular mechanisms of protein aggregation in mAb therapeutics;Biotechnology Advances;2023-10

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