Signal detection in real‐world data and confirmation in clinical trials: Diabetes as a case study for a conversation worth having-Reference-Cited by-同舟云学术

Signal detection in real‐world data and confirmation in clinical trials: Diabetes as a case study for a conversation worth having

Published:2023-07-13 Issue:18 Volume:129 Page:2769-2770
ISSN:0008-543X
Container-title:Cancer
language:en
Short-container-title:Cancer

Author:

Sharon Elad¹^ORCID,Othus Megan²,Quandt Zoe Eloise³⁴

Affiliation:

1. Cancer Therapy Evaluation Program Division of Cancer Treatment and Diagnosis National Cancer Institute Bethesda Maryland USA

2. Public Health Sciences Fred Hutchinson Cancer Center Seattle Washington USA

3. Division of Endocrinology and Metabolism Department of Medicine University of California, San Francisco San Francisco California USA

4. Diabetes Center University of California, San Francisco San Francisco California USA

Abstract

A real‐world data (RWD) analysis revealed potentially worse outcomes for diabetic patients with lung cancer receiving immunotherapy. The effort emphasizes the need to bridge RWD and randomized clinical trials to enhance understanding of how comorbid conditions affect overall patient health.

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference12 articles.

1. Broadening Eligibility Criteria to Make Clinical Trials More Representative: American Society of Clinical Oncology and Friends of Cancer Research Joint Research Statement

2. The Friends of Cancer Research Real‐World Data Collaboration Pilot 2.0: Methodological Recommendations from Oncology Case Studies

3. The Association Between Baseline Hepatic or Renal Function and Clinical Outcomes for Patients With Non‐Small Cell Lung Cancer Treated With a PD‐1/PD‐L1 Blocking Antibody Using Real‐World and Trial Data