Affiliation:
1. Department of Nuclear Medicine and PET Center the Second Hospital of Zhejiang University School of Medicine Hangzhou 310009 P. R. China
2. College of Chemical and Biological Engineering Zhejiang University Hangzhou 310058 P. R. China
3. MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 P.R. China
4. Key Laboratory of Polymer Ecomaterial Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P.R. China
Abstract
AbstractAggregation‐induced emission luminogens (AIEgens) in the second near‐infrared region (NIR‐II,1000‐1700 nm) have shown tremendous potential as theragnostic probe for tumor multimodal diagnostic imaging and combined treatment owing to their programmable optical, structural and functional properties. Herein, we presented a radionuclide 177Lu‐labeled AIEgen, 177Lu‐2TT‐oC6B dots, for NIR‐II fluorescence and SPECT/CT imaging‐guided tumor photothermal and radiopharmaceutical therapy. Intriguingly, 177Lu‐2TT‐oC6B self‐assembled into 10 nm dots, exhibited high NIR‐II fluorescence quantum yield (QY, 1.34 %) and unprecedented photothermal conversion efficiency (PCE, 70.3 %) in vitro, furtherly performed extremely long blood circulation (T1/2=52.4 h), persistent tumor accumulation and retention in tumor (NIR‐II SNR=5.56; SPECT SNR=36.59) via intravenous administration in vivo. Furthermore, upon NIR light activation and 177Lu irradiation, 177Lu‐2TT‐oC6B demonstrated great application potential in synergistic photothermal/radiopharmaceutical tumor therapy.
Funder
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities
Subject
General Chemistry,Biochemistry,Organic Chemistry