Vanadium‐catalyzed Hydration of 2‐Cyanopyrazine to Pyrazinamide with Unique Substrate Specificity
-
Published:2023-10-12
Issue:22
Volume:18
Page:
-
ISSN:1861-4728
-
Container-title:Chemistry – An Asian Journal
-
language:en
-
Short-container-title:Chemistry An Asian Journal
Author:
Guo Zhongxu1,
Du Zhongtian1ORCID,
Zhao Yanbin1,
Shen Xiaoyu1,
Liang Changhai12
Affiliation:
1. School of Chemical Engineering at Panjin Dalian University of Technology Panjin 124221 P. R. China
2. State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116024 P. R. China
Abstract
AbstractPyrazinamide is an important medicine used for the treatment of tuberculosis(TB). The preparation of pyrazinamide via catalytic hydration of 2‐cyanopyrazine is of great economic interest with high atomic economy. Heterogeneous non‐precious transition metal‐catalyzed hydration of nitriles under neutral reaction conditions would be rather attractive. Herein vanadium‐nitrogen‐carbon materials were fabricated and employed for selective hydration of nitriles using water as both the solvent and reactant. 2‐Cyanopyrazine could be smoothly converted into to pyrazinamide with unique substrate specificity. Additives with different N and O atoms could significantly affect hydration of 2‐cyanopyrazine due to competitive adsorption/coordination in the reaction system. This work provides a new approach for non‐precious metal catalyzed hydration of nitriles.
Funder
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities
Subject
General Chemistry,Biochemistry,Organic Chemistry