Affiliation:
1. Department of Chemistry National Institute of Technology Rourkela Odisha 769008 India
Abstract
AbstractPalladium‐catalyzed thioarylation of indoles by diaryl disulfides in the presence of phenyliododiacetate is reported. The directing potential of weakly coordinating aldehyde group present at 3‐position of indole was exploited for regioselective C2‐H thioarylation over the possible C4‐H functionalization. Mechanistic studies reveal that the process involves initial generation of thioaryl radical followed by sequential C−H activation, thiolate transfer, and reductive elimination.
Funder
Science and Engineering Research Board