Palladium‐Catalyzed Tandem Cyclization of Bromoalkynes, Anilines and CO: Access to 1,3‐Substituted Maleimides

Author:

Zeng Caijin1,Su Shaoting1,Fang Songjia1,Jiang Huangfeng1,Yang Shaorong1,Wu Wanqing1ORCID

Affiliation:

1. Key Laboratory of Functional Molecular Engineering of Guangdong Province State Key Laboratory of Luminescent Materials and Devices School of Chemistry and Chemical Engineering South China University of Technology Guangzhou 510640 P. R. China

Abstract

AbstractA novel palladium‐catalyzed three‐component carbonylation reaction for the assembly of various 1,3‐substituted maleimide derivatives from haloalkynes and simple anilines. The nucleophilic addition reaction of haloalkynes, anilines and CO, and insertion of carbonyl have been achieved sequentially in this reaction. The high chemo‐ and regioselectivities, as well as no need of expensive ligands or additives further illustrate the synthetic value of this approach.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Chemistry,Biochemistry,Organic Chemistry

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