Affiliation:
1. School of Chemistry and Chemical Engineering Yangzhou University Siwangting Road 180 225002 Yangzhou Jiangsu P. R. China
Abstract
AbstractA series of furoxan derivatives with N‐nitroso groups were synthesized in good yields by TBN initiated radical sp3 C−N bond cleavage of 1‐nitromethyl‐N‐aryltetrahydroisoquinolines. This reaction grafts the biologically important furoxan skeleton and N‐nitroso group into on molecule, greatly improving the molecular complexity in one step transformation. The mechanistic study shows that this reaction is mediated by the in situ generated α‐carbonyl nitrile oxide, which is afforded by TBN promoted C−N bond cleavage.
Funder
National Natural Science Foundation of China
Subject
General Chemistry,Biochemistry,Organic Chemistry
Cited by
3 articles.
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