Affiliation:
1. CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry University of Science and Technology of China Hefei Anhui 230026
2. Frontiers Science Center for Transformative Molecules (FSCTM) Zhangjiang Institute for Advanced Study Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 P. R. China.
Abstract
AbstractN,N,P‐Pincer nickel complexes effectively catalyze reaction of alcohols with benzylphosphine oxides to form alkenes in good yields. The protocol suits for a wide scope of substrates and generates only E‐configurated alkenes. The method also shows good compatibility of functional groups. Methoxy, methylthio, trifluoromethyl, ketal, fluoro, chloro, bromo, thienyl, and furyl groups are tolerated. The mechanism studies support that the reaction proceeds through catalytic dehydrogenation of alcohols to aldehydes or ketones followed by condensation with benzyldiphenylphosphine oxides in the presence of KOtBu.
Funder
National Natural Science Foundation of China