Harnessing Croconaine Organic Photosensitizers for a Milder Surface‐Mediated Transfection

Author:

Ferdinandus 1ORCID,Tan Wen Ling Lenice1ORCID,Tan Jie Ren1ORCID,Lee Hiang Kwee1ORCID,Zhu Qiang2,Ye Enyi2,Lee Chi‐Lik Ken13ORCID

Affiliation:

1. School of Chemistry Chemical Engineering and Biotechnology Nanyang Technological University 21 Nanyang Link Singapore 637371

2. Institute of Materials Research and Engineering (IMRE) Agency for Science, Technology, and Research (A*STAR) 2 Fusionopolis Way, Innovis Singapore 138634

3. Institute of Sustainability for Chemicals Energy and Environment (ISCE2) Agency for Science, Technology, and Research (A*STAR) 1 Pesek Road Singapore 627833

Abstract

AbstractPolydopamine‐based materials, notably Polydopamine‐polyethyleneimine (PDA‐PEI), have gained considerable interest for surface‐mediated transfection. However, the high laser power density required to achieve high transfection efficiency poses a significant challenge in preserving cell viability. An organic photosensitizer CRO32TMI was developed to improve the photothermal conversion capability of PDA‐PEI. The modified PDA‐PEI‐CRO32TMI exhibited remarkable photothermal and photostability properties upon NIR irradiation, enabling it to achieve better transfection efficiency at lower laser power density as compared to the traditional solution or lipid‐based transfection methods.

Funder

Ministry of Education - Singapore

Publisher

Wiley

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