Affiliation:
1. Henan Institute of Advanced Technology, College of Chemistry Zhengzhou University Zhengzhou 450001 P.R. China
Abstract
AbstractAlkoxylation of benzylic C(sp3)−H bonds has become one of the most important tools for the construction of benzyl ethers from feedstock chemicals. Herein, we reported a silver catalyzed alkoxylation of benzylic C(sp3)−H bonds employing potassium persulfate as an oxidant at room temperature. This strategy showed good functional‐group tolerance, site selectivity, and chemoselectivity. The reaction proceeded smoothly in the presence of various primary, secondary, and tertiary alcohol nucleophiles, affording corresponding benzyl ethers. Combined experimental studies provided mechanistic insights into the possible radical pathways. Furthermore, a possible mechanism was proposed for this method.
Funder
Startup Research Fund of Zhengzhou University
Subject
General Chemistry,Biochemistry,Organic Chemistry