Synthesis of ɑ‐Aryl‐oxindoles via Grignard Reaction with Isatin in the Presence of Diphenyl Phosphite

Author:

Zhang Xinxin X.1ORCID,Wang Pengkai K.2,Zhang Songlin L.2

Affiliation:

1. Oxford Suzhou Centre for Advanced Research Building A 388 Ruo Shui Road Suzhou Industrial Park Jiangsu 215123 P. R. China

2. Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials Science Dushu Lake Campus Soochow University Suzhou 215123 People's Republic of China

Abstract

AbstractA protocol has been developed for the synthesis of α‐aryl‐oxindoles from isatin and Grignard reagents in the presence of diphenyl phosphite for the first time. This reaction was conveniently carried out under mild conditions in a one‐pot fashion with moderate to excellent yields.

Funder

Priority Academic Program Development of Jiangsu Higher Education Institutions

National Natural Science Foundation of China

Publisher

Wiley

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