Rhodium‐Catalyzed [3+2]‐Cycloaddition of in‐situ Generated Nitrile Ylides with Nitrosoarenes

Author:

Yao Wei‐Zhong1,Cai Bao‐Gui1,Xuan Jun12ORCID

Affiliation:

1. Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials College of Chemistry & Chemical Engineering Anhui University Hefei Anhui 230601 People's Republic of China

2. Key Laboratory of Structure and Functional Regulation of Hybrid Materials Anhui University) Ministry of Education Hefei Anhui 230601 People's Republic of China

Abstract

AbstractHerein we report the rhodium‐catalyzed one‐pot three‐component reaction of diazo compounds, nitriles, and nitrosoarenes to construct 2,5‐dihydro‐1,2,4‐oxadiazole derivatives. Mechanistic studies indicate that the transformation may proceed through the formation of nitrile ylides intermediates, which then undergo [3+2]‐cycloaddition with nitrosoarenes. The strategy exhibits several synthetic advantages, including operational simplicity, good functional group tolerance, and scalability.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Chemistry,Biochemistry,Organic Chemistry

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