Mechanochemical Rhodium‐Catalyzed C−H Bond Amidation of Ferrocenes by Ball Milling

Abstract

AbstractA direct protocol for Rh‐catalyzed C−H amidation of ferrocenes in a ball mill using dioxazolones as the amide source under solvent‐free conditions was developed. The corresponding ortho‐aminated products were formed in 3 hours and the yields were up to 99% in the absence of base. This method could be a typically sustainable and environmental‐friendly alternative method to traditional methodologies, with the advantages of wide substrate range, good functional group tolerance and gram‐scale synthesis.