Gold(I)‐Catalyzed Regioselective Synthesis of Indenylidene Derivatives via 1,5‐Acryl Migration

Abstract

AbstractA novel gold (I)‐catalyzed synthetic strategy has been achieved for an efficient construction of indenylidene derivatives from substituted 1,6‐diynes. This reaction describes the unique reactivity of gold catalysis in facilitating the intramolecular [3,3]‐sigmatropic rearrangement, 5‐exo dig cyclization followed by 1,5‐migration of acryl group, resulting in the formation of substituted indenylidenes. Various substituted indenylidenes were successfully synthesized with up to 92 % yields. In this protocol, two new C−C bonds were sequentially formed atom economically in one pot.