Base‐catalyzed Effective C2‐Amidation of Azolium Salts Using Isocyanates under Mild Conditions

Abstract

AbstractAn unprecedented base‐catalyzed hydroarylation of isocyanates with azolium salts was developed, which follows a simple reaction pathway and provided facile access to diverse C2‐amidated azolium salts under mild conditions. Importantly, this methodology can also be applied for the successive C2‐amidation of a bisimidazolium salt with two different isocyanates to provide the corresponding unsymmetrically substituted bisamide derivatives. Notably, the obtained amidated salts can also serve as a prominent carbene surrogate for the synthesis of metal‐NHC complexes.