Affiliation:
1. College of Life Science and Engineering Lanzhou University of Technology Lanzhou 730050 P.R. China
2. School of Chemistry Sun Yat-Sen University Guangzhou 510006 P. R. China
Abstract
AbstractMetal complexes represented by platinum complexes play a very important role in cancer treatment due to their diverse chemical structures and anti‐tumor activities. Recently, ferroptosis has emerged as a newly occurring cell death form in the anti‐tumor process. It has been reported that metal complexes could inhibit the proliferation and metastasis of tumors and combat chemotherapy resistance by targeting ferroptosis. In this review, we briefly describe ferroptosis as a fundamental process for tumor suppression and triggering anti‐tumor immune responses. We summarize recent developments on metal complexes that induce ferroptosis. Finally, we outline the prospects for the application of metal complexes to the treatment of tumors based on ferroptosis and the associated problems that need to be solved, and discussed other potential research directions of metal complexes.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Gansu Province
Subject
General Chemistry,Biochemistry,Organic Chemistry