Affiliation:
1. Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical Engineering South China University of Technology 510640 Guangzhou P. R China
2. Guangdong Province Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region Shaoguan University 512005 Shaoguan P. R. China
Abstract
AbstractA palladium‐catalyzed cascade cyclization/alkenylation for the assembly of synthetically valuable isoxazolyl vinylsilane derivative has been accomplished. Easily accessible ynone oximes, and available vinylsilane agents were used as the reaction starting materials This protocol features broad substrate scope, good functional group tolerance, and good step‐ and atom‐economy. Remarkably, this approach provides a new approach for the construction of structurally diverse isoxazolyl‐containing vinylsilanes with high molecular complexity, showing a promising application in synthetic and pharmaceutical chemistry.
Funder
National Natural Science Foundation of China
National Key Research and Development Program of China
Subject
General Chemistry,Biochemistry,Organic Chemistry