Recent Advances in Detection of Hydroxyl Radical by Responsive Fluorescence Nanoprobes

Author:

Alanazi Mazen1,Yong Jiaxi2,Wu Miaomiao1,Zhang Zexi1,Tian Dihua1,Zhang Run1ORCID

Affiliation:

1. Australian Institute for Bioengineering and Nanotechnology The University of Queensland St. Lucia Queensland 4072 Australia

2. Queensland Alliance for Agriculture and Food Innovation (QAAFI) The University of Queensland St. Lucia Queensland 4072 Australia

Abstract

AbstractHydroxyl radical (•OH), a highly reactive oxygen species (ROS), is assumed as one of the most aggressive free radicals. This radical has a detrimental impact on cells as it can react with different biological substrates leading to pathophysiological disorders, including inflammation, mitochondrion dysfunction, and cancer. Quantification of this free radical in‐situ plays critical roles in early diagnosis and treatment monitoring of various disorders, like macrophage polarization and tumor cell development. Luminescence analysis using responsive probes has been an emerging and reliable technique for in‐situ detection of various cellular ROS, and some recently developed •OH responsive nanoprobes have confirmed the association with cancer development. This paper aims to summarize the recent advances in the characterization of •OH in living organisms using responsive nanoprobes, covering the production, the sources of •OH, and biological function, especially in the development of related diseases followed by the discussion of luminescence nanoprobes for •OH detection.

Funder

National Health and Medical Research Council

University of Queensland

Publisher

Wiley

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