Affiliation:
1. Department of Chemistry Indian Institute of Technology Bombay Powai Mumbai 400076 India
Abstract
AbstractHerein, we developed an efficient approach to access biologically relevant 2‐aminoquinolines and 1‐aminoisoquinolines from readily available N‐sulfonyl‐1,2,3‐triazoles and 2‐quinolones or 1‐isoquinolones. This transformation involves the selective O−H insertion of these derivatives onto the in situ generated Rh‐azavinyl carbenes (Rh‐AVC) followed by rearrangement. The reaction proceeds smoothly under operationally simple conditions and the protocol was found to be scalable.
Subject
General Chemistry,Biochemistry,Organic Chemistry