Affiliation:
1. Department of Chemistry SRM Institute of Science and Technology Kattankulathur Chennai 603203 India
2. Department of Chemistry SRM University AP Amaravati Andhra Pradesh 522502 India
Abstract
AbstractA palladium‐catalyzed denitrogenative transannulation strategy to access various 3‐substituted isocoumarin‐1‐imine frameworks using 1,2,3‐benzotriazin‐4(3H)‐ones and terminal alkynes is described. The reaction is highly regioselective and tolerates a wide range of functional groups. The reaction is believed to proceed via a five‐membered palladacycle intermediate extruding environmentally benign molecular nitrogen as a by‐product. The utility of this method was showcased through the one‐pot synthesis of biologically relevant 3‐substituted isocoumarin scaffolds.
Subject
General Chemistry,Biochemistry,Organic Chemistry