Affiliation:
1. State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences and Chemical Biology Center Peking University Xue Yuan Road No.38 Beijing 100191 China
Abstract
AbstractThe efficient synthesis of N‐glycosides via direct N‐glycosylation of amides/azacycles has been reported. The glycosylation of amides/azacycles with glycosyl halides in the presence of a catalytic amount of urea proceeded smoothly to provide the corresponding N‐glycosylated amides or nucleosides in good to excellent yields with 1,2‐trans‐stereoselectivity. Moreover, by the addition of terpyridine, the 1,2‐cis‐stereoselectivity was achieved.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Subject
General Chemistry,Biochemistry,Organic Chemistry