Group 2 innate lymphoid cells are elevated and activated in chronic rhinosinusitis with nasal polyps

Author:

Poposki Julie A.1,Klingler Aiko I.1,Tan Bruce K.2,Soroosh Pejman3,Banie Homayon3,Lewis Gavin3,Hulse Kathryn E.1,Stevens Whitney W.1,Peters Anju T.1,Grammer Leslie C.1,Schleimer Robert P.12,Welch Kevin C.2,Smith Stephanie S.2,Conley David B.2,Raviv Joseph R.4,Karras James G.3,Akbari Omid5,Kern Robert C.12,Kato Atsushi12ORCID

Affiliation:

1. Division of Allergy-Immunology; Department of Medicine; Northwestern University Feinberg School of Medicine; Chicago Illinois USA

2. Department of Otolaryngology; Northwestern University Feinberg School of Medicine; Chicago Illinois USA

3. Janssen Research and Development; San Diego California USA

4. Division of Otolaryngology-Head and Neck Surgery, NorthShore University HealthSystem, The University of Chicago; Pritzker School of Medicine; Evanston Illinois USA

5. Department of Molecular Microbiology and Immunology, Keck School of Medicine; University of Southern California; Los Angeles California USA

Funder

National Heart, Lung, and Blood Institute

National Institute of Allergy and Infectious Diseases

Ernest S. Bazley Foundation

Janssen Research and Development

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference33 articles.

1. European position paper on rhinosinusitis and nasal polyps 2012;Fokkens;Rhinol. Suppl,2012

2. Immunopathology of chronic rhinosinusitis;Kato;Allergol. Int,2015

3. Heterogeneous inflammatory patterns in chronic rhinosinusitis without nasal polyps in Chicago, Illinois;Tan;J. Allergy Clin. Immunol,2017

4. Human innate lymphoid cells;Hazenberg;Blood,2014

5. Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161;Mjosberg;Nat. Immunol,2011

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