Downregulation by organic nitrogen of AOX1 promoter used for controlled expression of foreign genes in the yeast Pichia pastoris
Author:
Affiliation:
1. Escuela de Ingeniería BioquímicaPontificia Universidad Católica de Valparaíso Valparaíso Chile
2. Microbial Processes and Interactions, TERRA Teaching and Research Centre, Gembloux Agro Bio TechUniversity of Liege Gembloux Belgium
Funder
Consejo Nacional de Innovación, Ciencia y Tecnología
Wallonie-Bruxelles International
Pontificia Universidad Católica de Valparaíso
Publisher
Wiley
Subject
Genetics,Applied Microbiology and Biotechnology,Biochemistry,Bioengineering,Biotechnology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/yea.3381
Reference28 articles.
1. The growth of Pichia pastoris Mut+ on methanol–glycerol mixtures fits to interactive dual-limited kinetics: model development and application to optimised fed-batch operation for heterologous protein production
2. Influence of methanol/sorbitol co-feeding rate on pAOX1 induction in a Pichia pastoris Mut+ strain in bioreactor with limited oxygen transfer rate
3. Enhanced production of insect raw-starch-digesting alpha-amylase accompanied by high erythritol synthesis in recombinant Yarrowia lipolytica fed-batch cultures at high-cell-densities
4. Secretion of human interleukin-2 fused with green fluorescent protein in recombinatn pichia pastoris
5. Production of mouse epidermal growth factor in yeast: high-level secretion using Pichia pastoris strains containing multiple gene copies
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1. Formate from THF-C1 metabolism induces the AOX1 promoter in formate dehydrogenase-deficientPichia pastoris;2024-05-29
2. Customizing amino acid metabolism of Pichia pastoris for recombinant protein production;Biotechnology Journal;2023-09-13
3. Co-feeding strategy alleviates hypoxic stress in large-scale bioreactor for optimal production of secretory recombinant proteins in Pichia pastoris;Journal of Biotechnology;2023-08
4. Engineering the methylotrophic yeast Ogataea polymorpha for lactate production from methanol;Frontiers in Bioengineering and Biotechnology;2023-06-30
5. Is heterogeneity in large-scale bioreactors a real problem in recombinant protein synthesis by Pichia pastoris?;Applied Microbiology and Biotechnology;2023-02-27
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