Ligustrazine suppresses neuron apoptosis via the Bax/Bcl-2 and caspase-3 pathway in PC12 cells and in rats with vascular dementia-Reference-Cited by-同舟云学术

Ligustrazine suppresses neuron apoptosis via the Bax/Bcl-2 and caspase-3 pathway in PC12 cells and in rats with vascular dementia

Published:2017-12-16 Issue:1 Volume:70 Page:60-70
ISSN:1521-6543
Container-title:IUBMB Life
language:en
Short-container-title:IUBMB Life

Author:

Zhao Tengfei¹^ORCID,Fu Yingxue²³,Sun Hao²³,Liu Xiaoquan¹

Affiliation:

1. Center of Drug Metabolism and Pharmacokinetics; China Pharmaceutical University; Nanjing China

2. School of Pharmacy; Nanjing University of Chinese Medicine; Nanjing China

3. Key Laboratory of Efficacy and Safety Evaluation of Traditional Chinese Medicine in Jiangsu Province; Nanjing China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Cell Biology,Clinical Biochemistry,Genetics,Molecular Biology,Biochemistry

Reference38 articles.

1. Ligustrazine reduces blood-brain barrier permeability in a rat model of focal cerebral ischemia and reperfusion;Tan;Exp. Ther. Med.,2015

2. Ligustrazine monomer against cerebral ischemia/reperfusion injury;Gao;Neural Regen. Res.,2015

3. Observation on curative effect of acute ischemic cerebrovascular disease treated with different dosage of ligustrazine;Cai;Zhongguo Zhong Xi Yi Jie He Za Zhi,2000

4. Effect of ligustrazine on nNOS expression and neuranagenesis in adult rats after cerebral ischemia-reperfusion injury;Qi;Nan Fang Yi Ke Da Xue Xue Bao,2007

5. A novel ligustrazine derivative T-VA prevents neurotoxicity in differentiated PC12 cells and protects the brain against ischemia injury in MCAO rats;Li;Int. J. Mol. Sci.,2015

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