Axially Coordinated Gold Nanoclusters Tailoring Fe–N–C Nanozymes for Enhanced Oxidase‐Like Specificity and Activity

Abstract

AbstractMetal–organic frameworks (MOF) derived nitrogen‐doped carbon‐supported monodisperse Fe (Fe–N–C) catalysts are intensively studied, but great challenges remain in understanding the relationship between the coordination structure and the performance of Fe–N–C nanozymes. Herein, a novel nanocluster ligand‐bridging strategy is proposed for constructing Fe‐S1N4 structures with axially coordinated S and Au nanoclusters on ZIF‐8 derived Fe–N–C (labeled Aux/Fe‐S1N4‐C). The axial Au nanoclusters facilitate electron transfer to Fe active sites, utilizing the bridging ligand S as a medium, thereby enhancing the oxygen adsorption capacity of composite nanozymes. Compared to Fe‐N‐C, Aux/Fe‐S1N4‐C exhibits high oxidase‐like specificity and activity, and holds great potential for detecting acetylcholinesterase activity with a detection limit of 5.1 µU mL−1, surpassing most reported nanozymes.