A Designed α ‐GalCer Analog Promotes Considerable Th1 Cytokine Response by Activating the CD1d‐iNKT Axis and CD11b‐Positive Monocytes/Macrophages-Reference-Cited by-同舟云学术

A Designed α ‐GalCer Analog Promotes Considerable Th1 Cytokine Response by Activating the CD1d‐iNKT Axis and CD11b‐Positive Monocytes/Macrophages

Published:2020-06-08 Issue:14 Volume:7 Page:2000609
ISSN:2198-3844
Container-title:Advanced Science
language:en
Short-container-title:Adv. Sci.

Author:

Ma Juan¹²,He Peng¹³,Zhao Chuanfang¹³,Ren Quanzhong¹²,Dong Zheng¹²,Qiu Jiahuang¹²,Jing Yang¹⁴,Liu Sijin¹²^ORCID,Du Yuguo¹³

Affiliation:

1. State Key Laboratory of Environmental Chemistry and EcotoxicologyResearch Center for Eco‐Environmental SciencesChinese Academy of Sciences Beijing 100085 P. R. China

2. School of Environmental SciencesUniversity of Chinese Academy of Sciences Beijing 100049 P. R. China

3. School of Chemical SciencesUniversity of Chinese Academy of Sciences Beijing 100049 P. R. China

4. National Engineering Research Center for Carbohydrate SynthesisJiangxi Normal University Nanchang Jiangxi 330022 China

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Natural Science Foundation of Beijing Municipality

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202000609

Reference57 articles.

1. Structure-Activity Relationship of .alpha.-Galactosylceramides against B16-Bearing Mice

2. CD1d-mediated Recognition of an α-Galactosylceramide by Natural Killer T Cells Is Highly Conserved through Mammalian Evolution

3. Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis

4. Avidity of CD1d-ligand-receptor ternary complex contributes to T-helper 1 (Th1) polarization and anticancer efficacy

5. Enhanced TCR Footprint by a Novel Glycolipid Increases NKT-Dependent Tumor Protection

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