Mistranslation Drives Alterations in Protein Levels and the Effects of a Synonymous Variant at the Fibroblast Growth Factor 21 Locus

Author:

Bayoumi Ali1ORCID,Elsayed Asmaa1,Han Shuanglin1,Petta Salvatore2,Adams Leon A.3,Aller Rocio4,Khan Anis1,García‐Monzón Carmelo5,Arias‐Loste María Teresa6,Miele Luca7,Latchoumanin Olivier1,Alenizi Shafi1,Gallego‐Durán Rocio8,Fischer Janett9,Berg Thomas9,Craxì Antonio2,Metwally Mayada1,Qiao Liang1,Liddle Christopher1,Yki‐Järvinen Hannele10,Bugianesi Elisabetta11,Romero‐Gomez Manuel8,George Jacob1,Eslam Mohammed1

Affiliation:

1. Storr Liver Centre Westmead Institute for Medical Research Westmead Hospital and University of Sydney Westmead NSW 2145 Australia

2. Section of Gastroenterology and Hepatology PROMISE University of Palermo Palermo 90133 Italy

3. Medical School Sir Charles Gairdner Hospital Unit University of Western Australia Nedlands WA 6009 Australia

4. Gastroenterology Hospital Clinico Universitario de Valladolid School of Medicine Valladolid University Valladolid 47002 Spain

5. Liver Research Unit Instituto de Investigacion Sanitaria Princesa University Hospital Santa Cristina CIBERehd Madrid 28009 Spain

6. Gastroenterology and Hepatology Department Marqués de Valdecilla University Hospital Santander 39008 Spain

7. Department of Internal Medicine Catholic University of the Sacred Heart Rome 20123 Italy

8. Virgen del Rocío University Hospital Institute of Biomedicine of Seville Sevilla 41013 Spain

9. Division of Hepatology Department of Medicine II Leipzig University Medical Center Leipzig 04103 Germany

10. Department of Medicine University of Helsinki and Helsinki University Hospital and Minerva Foundation Institute for Medical Research Helsinki 00290 Finland

11. Division of Gastroenterology Department of Medical Science University of Turin Turin 10124 Italy

Funder

National Health and Medical Research Council

Horizon 2020 Framework Programme

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

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