Affiliation:
1. State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and Engineering University of Electronic Science and Technology of China (UESTC) Chengdu 610054 P. R. China
2. Department of Biomedical Engineering City University of Hong Kong Hong Kong P. R. China
3. Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception Institute of Optoelectronics Fudan University Shanghai 200433 P. R. China
4. Hong Kong Center for Cerebra‐Cardiovascular Health Engineering Hong Kong Science Park New Territories Hong Kong P. R. China
5. Department of Electrical and Electronic Engineering The University of Hong Kong Hong Kong SAR P. R. China
Abstract
AbstractA critical challenge lies in the development of the next‐generation neural interface, in mechanically tissue‐compatible fashion, that offer accurate, transient recording electrophysiological (EP) information and autonomous degradation after stable operation. Here, an ultrathin, lightweight, soft and multichannel neural interface is presented based on organic‐electrochemical‐transistor‐(OECT)‐based network, with capabilities of continuous high‐fidelity mapping of neural signals and biosafety active degrading after performing functions. Such platform yields a high spatiotemporal resolution of 1.42 ms and 20 µm, with signal‐to‐noise ratio up to ≈37 dB. The implantable OECT arrays can well establish stable functional neural interfaces, designed as fully biodegradable electronic platforms in vivo. Demonstrated applications of such OECT implants include real‐time monitoring of electrical activities from the cortical surface of rats under various conditions (e.g., narcosis, epileptic seizure, and electric stimuli) and electrocorticography mapping from 100 channels. This technology offers general applicability in neural interfaces, with great potential utility in treatment/diagnosis of neurological disorders.
Funder
National Natural Science Foundation of China
City University of Hong Kong
Subject
General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)
Cited by
11 articles.
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