Impaired Neurovascular Coupling and Increased Functional Connectivity in the Frontal Cortex Predict Age‐Related Cognitive Dysfunction-Reference-Cited by-同舟云学术

Impaired Neurovascular Coupling and Increased Functional Connectivity in the Frontal Cortex Predict Age‐Related Cognitive Dysfunction

Published:2023-12-28 Issue: Volume: Page:
ISSN:2198-3844
Container-title:Advanced Science
language:en
Short-container-title:Advanced Science

Author:

Mukli Peter¹²³⁴^ORCID,Pinto Camila B.¹²^ORCID,Owens Cameron D.¹²^ORCID,Csipo Tamas¹²⁴⁵^ORCID,Lipecz Agnes¹²⁴,Szarvas Zsofia¹²⁴^ORCID,Peterfi Anna¹²⁴^ORCID,Langley Ana Clara da Costa Pinaffi¹²,Hoffmeister Jordan⁵^ORCID,Racz Frigyes Samuel³⁶^ORCID,Perry Jonathan W.¹^ORCID,Tarantini Stefano¹²⁴⁷⁸^ORCID,Nyúl‐Tóth Ádám¹²⁴^ORCID,Sorond Farzaneh A.⁹^ORCID,Yang Yuan¹⁰¹¹¹²^ORCID,James Judith A.¹¹³¹⁴¹⁵^ORCID,Kirkpatrick Angelia C.¹⁶^ORCID,Prodan Calin I.¹⁶¹⁷,Toth Peter⁴¹⁸¹⁹²⁰,Galindo Juliette⁵^ORCID,Gardner Andrew W.²¹^ORCID,Sonntag William E.¹^ORCID,Csiszar Anna¹²⁴⁸^ORCID,Ungvari Zoltan¹²⁴⁷⁸^ORCID,Yabluchanskiy Andriy¹²⁷⁸^ORCID

Affiliation:

1. Oklahoma Center for Geroscience and Healthy Brain Aging University of Oklahoma Health Sciences Center 1122 NE 13th Street Oklahoma City OK 73117 USA

2. Vascular Cognitive Impairment and Neurodegeneration Program Department of Neurosurgery University of Oklahoma Health Sciences Center Oklahoma City OK 73117 USA

3. Department of Physiology Faculty of Medicine Semmelweis University Budapest H‐1094 Hungary

4. International Training Program in Geroscience Doctoral School of Basic and Translational Medicine/Department of Public Health Semmelweis University Budapest H‐1085 Hungary

5. Department of Cardiology Division of Clinical Physiology Faculty of Medicine University of Debrecen Debrecen H‐4032 Hungary

6. Department of Neurology Dell Medical School University of Texas at Austin Austin TX 78712 USA

7. Department of Health Promotion Sciences College of Public Health University of Oklahoma Health Sciences Center Oklahoma City OK 73104 USA

8. Peggy and Charles Stephenson Cancer Center University of Oklahoma Health Sciences Center Oklahoma City OK 73104 USA

9. Department of Neurology Division of Stroke and Neurocritical Care Northwestern University Feinberg School of Medicine 303 E. Chicago Ave. Chicago IL 60611 USA

10. Stephenson School of Biomedical Engineering The University of Oklahoma Tulsa OK 73019 USA

11. Department of Physical Therapy and Human Movement Sciences Northwestern University Feinberg School of Medicine Chicago IL 60611 USA

12. Department of Rehabilitation Sciences University of Oklahoma Health Science Center Oklahoma City OK 73117 USA

13. Arthritis & Clinical Immunology Research Program Oklahoma Medical Research Foundation 825 NE 13^th Street Oklahoma City OK 73104 USA

14. Department of Internal Medicine University of Oklahoma Health Sciences Center Oklahoma City OK 73117 USA

15. Department of Pathology University of Oklahoma Health Sciences Center Oklahoma City OK 73104 USA

16. Veterans Affairs Medical Center Oklahoma City OK 73104 USA

17. Department of Neurology University of Oklahoma Health Sciences Center Oklahoma City OK 73104 USA

18. Department of Neurosurgery Medical School University of Pecs Pecs H‐7623 Hungary

19. Institute for Translational Medicine Medical School University of Pecs Pecs H‐7624 Hungary

20. ELKH‐PTE Clinical Neuroscience MR Research Group Pecs H‐7624 Hungary

21. Department of Physical Medicine and Rehabilitation Penn State College of Medicine 700 HMC Crescent Road Hershey PA 17033 USA

Abstract

AbstractImpaired cerebrovascular function contributes to the genesis of age‐related cognitive decline. In this study, the hypothesis is tested that impairments in neurovascular coupling (NVC) responses and brain network function predict cognitive dysfunction in older adults. Cerebromicrovascular and working memory function of healthy young (n = 21, 33.2±7.0 years) and aged (n = 30, 75.9±6.9 years) participants are assessed. To determine NVC responses and functional connectivity (FC) during a working memory (n‐back) paradigm, oxy‐ and deoxyhemoglobin concentration changes from the frontal cortex using functional near‐infrared spectroscopy are recorded. NVC responses are significantly impaired during the 2‐back task in aged participants, while the frontal networks are characterized by higher local and global connection strength, and dynamic FC (p < 0.05). Both impaired NVC and increased FC correlate with age‐related decline in accuracy during the 2‐back task. These findings suggest that task‐related brain states in older adults require stronger functional connections to compensate for the attenuated NVC responses associated with working memory load.

Funder

American Heart Association

National Institute of Neurological Disorders and Stroke

National Cancer Institute

National Institutes of Health

National Science Foundation

National Cancer Center

U.S. Department of Veterans Affairs

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202303516

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