Affiliation:
1. Department of Chemical Engineering and Applied Chemistry University of Toronto 200 College Street Toronto ON M5S 3E5 Canada
2. Donnelly Centre for Cellular and Biomolecular Research University of Toronto 160 College Street Toronto ON M5S 3E1 Canada
3. Institute of Biomedical Engineering 164 College Street Toronto ON M5S 3G9 Canada
Abstract
AbstractThe complex anatomy and physiological barriers of the eye make delivering ocular therapeutics challenging. Generally, effective drug delivery to the eye is hindered by rapid clearance and limited drug bioavailability. Biomaterial‐based approaches have emerged to enhance drug delivery to ocular tissues and overcome existing limitations. In this review, some of the most promising long‐acting injectables (LAIs) in ocular drug delivery are explored, focusing on novel design strategies to improve therapeutic outcomes. LAIs are designed to enable sustained therapeutic effects, thereby extending local drug residence time and facilitating controlled and targeted drug delivery. Moreover, LAIs can be engineered to enhance drug targeting and penetration across ocular physiological barriers.
Subject
General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)