A Macromolecule Reversing Antibiotic Resistance Phenotype and Repurposing Drugs as Potent Antibiotics

Author:

Ding Xin12,Yang Chuan2,Moreira Wilfried3,Yuan Peiyan1,Periaswamy Balamurugan2,Sessions Paola Florez4,Zhao Huimin1,Tan Jeremy2,Lee Ashlynn2,Ong Kai Xun3,Park Nathaniel5,Liang Zhen Chang2,Hedrick James L.5,Yang Yi Yan2ORCID

Affiliation:

1. School of Pharmaceutical Sciences (Shenzhen) Sun Yat‐sen University Shenzhen 518107 China

2. Institute of Bioengineering and Nanotechnology 31 Biopolis Way, The Nanos Singapore 138669 Singapore

3. Singapore‐MIT Alliance for Research and Technology (SMART) 1 CREATE Way Singapore 138602 Singapore

4. Genome Institute of Singapore 60 Biopolis Street, Genome Singapore 138672 Singapore

5. IBM Almaden Research Center 650 Harry Road San Jose CA 95120 USA

Funder

Biomedical Research Council

International Business Machines Corporation

National Natural Science Foundation of China

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

Reference61 articles.

1. W H Organization Antibacterial agents in clinical development—an analysis of the antibacterial clinical development pipeline including Mycobacterium tuberculosis http://apps.who.int/iris/bitstream/10665/258965/1/WHO‐EMP‐IAU‐2017.11‐eng.pdf(accessed: April2020).

2. Antibacterial drug discovery in the resistance era

3. Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria

4. Combination Therapy for Treatment of Infections with Gram-Negative Bacteria

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