Bioengineered Pancreas–Liver Crosstalk in a Microfluidic Coculture Chip Identifies Human Metabolic Response Signatures in Prediabetic Hyperglycemia

Author:

Zandi Shafagh Reza12,Youhanna Sonia1,Keulen Jibbe1234,Shen Joanne X.1,Taebnia Nayere1,Preiss Lena C.15,Klein Kathrin34,Büttner Florian A.34,Bergqvist Mikael2,van der Wijngaart Wouter2,Lauschke Volker M.134ORCID

Affiliation:

1. Department of Physiology and Pharmacology Karolinska Institutet Stockholm 17711 Sweden

2. Division of Micro‐ and Nanosystems KTH Royal Institute of Technology Stockholm 10044 Sweden

3. Dr Margarete Fischer‐Bosch Institute of Clinical Pharmacology 70376 Stuttgart Germany

4. University of Tuebingen 72074 Tuebingen Germany

5. Department of Drug Metabolism and Pharmacokinetics (DMPK) The Healthcare Business of Merck KGaA 64293 Darmstadt Germany

Funder

Vetenskapsrådet

Innovative Medicines Initiative

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

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