Affiliation:
1. Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Shanghai 201204 China
2. Shanghai Frontier Innovation Research Institute Shanghai 201108 China
3. Shanghai Stomatological Hospital Fudan University Shanghai 200031 China
4. Wuhan Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China
5. Hubei Key Laboratory of Molecular Imaging Wuhan 430022 China
6. Key Laboratory of Biological Targeted Therapy the Ministry of Education Wuhan 430022 China
Abstract
AbstractDNA has been used as a robust material for the building of a variety of nanoscale structures and devices owing to its unique properties. Structural DNA nanotechnology has reported a wide range of applications including computing, photonics, synthetic biology, biosensing, bioimaging, and therapeutic delivery, among others. Nevertheless, the foundational goal of structural DNA nanotechnology is exploiting DNA molecules to build three‐dimensional crystals as periodic molecular scaffolds to precisely align, obtain, or collect desired guest molecules. Over the past 30 years, a series of 3D DNA crystals have been rationally designed and developed. This review aims to showcase various 3D DNA crystals, their design, optimization, applications, and the crystallization conditions utilized. Additionally, the history of nucleic acid crystallography and potential future directions for 3D DNA crystals in the era of nanotechnology are discussed.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Shanghai Municipality
Subject
General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)
Cited by
7 articles.
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