Protein Scaffold‐Based Multimerization of Soluble ACE2 Efficiently Blocks SARS‐CoV‐2 Infection In Vitro and In Vivo

Author:

Kayabolen Alisan1ORCID,Akcan Ugur1ORCID,Özturan Doğancan1ORCID,Ulbegi‐Polat Hivda2ORCID,Sahin Gizem Nur1ORCID,Pinarbasi‐Degirmenci Nareg1ORCID,Bayraktar Canan1ORCID,Soyler Gizem1ORCID,Sarayloo Ehsan13ORCID,Nurtop Elif4ORCID,Ozer Berna4ORCID,Guney‐Esken Gulen4ORCID,Barlas Tayfun4ORCID,Yildirim Ismail Selim2,Dogan Ozlem45ORCID,Karahuseyinoglu Sercin16ORCID,Lack Nathan A.17ORCID,Kaya Mehmet1,Albayrak Cem13ORCID,Can Fusun45ORCID,Solaroglu Ihsan18ORCID,Bagci‐Onder Tugba1ORCID

Affiliation:

1. Koç University Research Center for Translational Medicine (KUTTAM) Koç University Istanbul 34450 Turkey

2. Genetic Engineering and Biotechnology Institute TUBITAK Marmara Research Center Kocaeli 41470 Turkey

3. Department of Biotechnology Beykoz Institute of Life Sciences and Biotechnology (BILSAB) Bezmialem Vakif University Istanbul 34820 Turkey

4. Koç University Isbank Center for Infectious Diseases (KUISCID) Istanbul 34010 Turkey

5. Koç University School of Medicine Department of Medical Microbiology Istanbul 34010 Turkey

6. Koç University School of Medicine, Department of Histology and Embryology Istanbul 34450 Türkiye

7. Vancouver Prostate Centre University of British Columbia Vancouver BC V6H 3Z6 Canada

8. Department of Basic Sciences Loma Linda University Loma Linda CA 92354 USA

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

Reference86 articles.

1. The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

2. A Novel Coronavirus from Patients with Pneumonia in China, 2019

3. WHO. WHO Director‐General's opening remarks at the media briefing on COVID‐19 –11 March 2020 https://www.who.int/director‐general/speeches/detail/who‐director‐general‐s‐opening‐remarks‐at‐the‐media‐briefing‐on‐covid‐19‐11‐march‐2020(accessed: December 2020).

4. W. H. O. W. H. O. Coronavirus (COVID‐19) Dashboard https://covid19.who.int/(accessed: March 2022).

5. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

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