Affiliation:
1. Department of Orthopaedics The First Affiliated Hospital of Soochow University Orthopaedic Institute, Medical College Soochow University Suzhou Jiangsu 215006 China
2. Department of Orthopaedics The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University Changzhou Jiangsu 213000 China
3. Institute for Advanced Materials School of Materials Science and Engineering Jiangsu University Zhenjiang Jiangsu 212013 China
4. Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China
Abstract
AbstractOver the last decade, adipose‐derived stem cells (ADSCs) have attracted increasing attention in the field of regenerative medicine. ADSCs appear to be the most advantageous cell type for regenerative therapies owing to their easy accessibility, multipotency, and active paracrine activity. This review highlights current challenges in translating ADSC‐based therapies into clinical settings and discusses novel strategies to overcome the limitations of ADSCs. To further establish ADSC‐based therapies as an emerging platform for regenerative medicine, this review also provides an update on the advancements in this field, including fat grafting, wound healing, bone regeneration, skeletal muscle repair, tendon reconstruction, cartilage regeneration, cardiac repair, and nerve regeneration. ADSC‐based therapies are expected to be more tissue‐specific and increasingly important in regenerative medicine.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Jiangsu Province
Subject
General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)
Cited by
42 articles.
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