Development of Neutralization Breadth against Diverse HIV‐1 by Increasing Ab–Ag Interface on V2

Author:

Gao Nan1,Gai Yanxin1,Meng Lina1,Wang Chu1,Wang Wei23,Li Xiaojun4,Gu Tiejun1,Louder Mark K.5,Doria‐Rose Nicole A.5,Wiehe Kevin6,Nazzari Alexandra F.5,Olia Adam S.5,Gorman Jason5,Rawi Reda5,Wu Wenmin7,Smith Clayton7,Khant Htet7,de Val Natalia7,Yu Bin1,Luo Junhong8,Niu Haitao8,Tsybovsky Yaroslav7,Liao Huaxin8,Kepler Thomas B.9,Kwong Peter D.5ORCID,Mascola John R.5,Qin Chuan23,Zhou Tongqing5ORCID,Yu Xianghui110,Gao Feng148ORCID

Affiliation:

1. National Engineering Laboratory for AIDS Vaccine, School of Life Sciences Jilin University Changchun Jilin Province 130012 China

2. Institute of Laboratory Animal Science Chinese Academy of Medical Sciences Beijing 100021 China

3. Comparative Medicine Center Peking Union Medical College Beijing 100021 China

4. Department of Medicine Duke University School of Medicine Durham NC 27710 USA

5. Vaccine Research Center, National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda MD 20892 USA

6. Duke University Human Vaccine Institute Duke University School of Medicine Durham NC 27710 USA

7. Cancer Research Technology Program, Frederick National Laboratory for Cancer Research Leidos Biomedical Research Inc. Frederick MD 21701 USA

8. Institute of Molecular and Medical Virology, School of Medicine Jinan University Guangzhou Guangdong Province 510632 China

9. Department of Microbiology Boston University Boston MA 02215 USA

10. Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences Jilin University Changchun Jilin Province 130012 China

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Program for Jilin University Science and Technology Innovative Research Team

National Institute of Allergy and Infectious Diseases

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

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