Copper Promotes Tumorigenesis by Activating the PDK1‐AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner

Author:

Guo Jianping12,Cheng Ji13,Zheng Nana4,Zhang Xiaomei2,Dai Xiaoming1,Zhang Linli5,Hu Changjiang1,Wu Xueji2,Jiang Qiwei2,Wu Depei4,Okada Hitoshi6,Pandolfi Pier Paolo7,Wei Wenyi1ORCID

Affiliation:

1. Department of Pathology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA

2. Institute of Precision Medicine the First Affiliated Hospital Sun Yat‐sen University Guangzhou Guangdong 510275 China

3. Department of Gastrointestinal Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430022 China

4. National Clinical Research Center for Hematologic Diseases Jiangsu Institute of Hematology The First Affiliated Hospital of Soochow University Suzhou Jiangsu 215000 China

5. Department of Oncology Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China

6. Department of Biochemistry Kindai University Faculty of Medicine 377‐2 Ohno‐Higashi Osaka‐Sayama Osaka 589‐8511 Japan

7. Division of Genetics Department of Medicine Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

National Cancer Institute

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

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