Affiliation:
1. Schulich Faculty of Chemistry and the Resnick Sustainability Center for Catalysis Technion – Israel Institute of Technology Haifa 3200008 Israel
Abstract
AbstractUnstrained C─C bond activation is attained in homopolymers through mechanochemical bond scission followed by functionalization to yield mostly semi‐telechelic polymer chains. Ball milling poly(ethylene oxide) (PEO) in the presence of 1‐(bromoacetyl)pyrene (BAPy) yields the pyrene terminated PEO. Similarly, milling with 2,4′‐dibromoacetophenone followed by Suzuki coupling allows the introduction of various aryl end groups. PEOs with a molecular weight below 20 kDa show no functionalization, supporting a mechanochemical mechanism. The protocol is also tested with doxorubicin, yielding the drug‐polymer conjugate. PEO halogenation is also demonstrated by milling PEO with iodine, N‐bromosuccinimide, or N‐iodosuccinimide, which can then be reacted with an amine substituted anthracene. Grinding additional carbon polymers with BAPy indicates that this functionalization method is general for different polymer chemistries.
Funder
Israel Science Foundation
Subject
General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)