Biodegradable Cardiac Occluder with Surface Modification by Gelatin–Peptide Conjugate to Promote Endogenous Tissue Regeneration
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Published:2023-11-20
Issue:2
Volume:11
Page:
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ISSN:2198-3844
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Container-title:Advanced Science
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language:en
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Short-container-title:Advanced Science
Author:
Kong Pengxu1,
Liu Xiang2,
Li Zefu1,
Wang Jingrong2,
Gao Rui2,
Feng Shuyi1,
Li Hang1,
Zhang Fengwen1,
Feng Zujian2,
Huang Pingsheng2,
Wang Shouzheng13,
Zhuang Donglin1,
Ouyang Wenbin13,
Wang Weiwei23ORCID,
Pan Xiangbin13
Affiliation:
1. Department of Structural Heart Disease National Center for Cardiovascular Disease China & State Key Laboratory of Cardiovascular Disease Fuwai Hospital Chinese Academy of Medical Sciences & Peking Union Medical College National Health Commission Key Laboratory of Cardiovascular Regeneration Medicine National Clinical Research Center for Cardiovascular Diseases Beijing 100037 China
2. Tianjin Key Laboratory of Biomaterial Research Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin 300192 China
3. Key Laboratory of Innovative Cardiovascular Devices Chinese Academy of Medical Sciences Beijing 100037 China
Abstract
AbstractTranscatheter intervention has been the preferred treatment for congenital structural heart diseases by implanting occluders into the heart defect site through minimally invasive access. Biodegradable polymers provide a promising alternative for cardiovascular implants by conferring therapeutic function and eliminating long‐term complications, but inducing in situ cardiac tissue regeneration remains a substantial clinical challenge. PGAG (polydioxanone/poly (l‐lactic acid)–gelatin–A5G81) occluders are prepared by covalently conjugating biomolecules composed of gelatin and layer adhesive protein‐derived peptides (A5G81) to the surface of polydioxanone and poly (l‐lactic acid) fibers. The polymer microfiber–biomacromolecule–peptide frame with biophysical and biochemical cues could orchestrate the biomaterial–host cell interactions, by recruiting endogenous endothelial cells, promoting their adhesion and proliferation, and polarizing immune cells into anti‐inflammatory phenotypes and augmenting the release of reparative cytokines. In a porcine atrial septal defect (ASD) model, PGAG occluders promote in situ tissue regeneration by accelerating surface endothelialization and regulating immune response, which mitigate inflammation and fibrosis formation, and facilitate the fusion of occluder with surrounding heart tissue. Collectively, this work highlights the modulation of cell–biomaterial interactions for tissue regeneration in cardiac defect models, ensuring endothelialization and extracellular matrix remodeling on polymeric scaffolds. Bioinspired cell–material interface offers a highly efficient and generalized approach for constructing bioactive coatings on medical devices.
Funder
Fundamental Research Funds for the Central Universities
Sanming Project of Medicine in Shenzen Municipality
National Natural Science Foundation of China
National Key Research and Development Program of China
Subject
General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)