Affiliation:
1. Department of Nuclear Medicine, TUM School of Medicine Klinikum rechts der Isar of Technical University of Munich 81675 Munich Germany
2. NVision Imaging Technologies GmbH 89081 Ulm Germany
3. Munich Institute of Biomedical Engineering Technical University of Munich 85748 Garching Germany
4. German Cancer Consortium (DKTK) Partner Site Munich and German Cancer Research Center (DKFZ) Im Neuenheimer Feld 280 69120 Heidelberg Germany
Abstract
AbstractHyperpolarization techniques increase nuclear spin polarization by more than four orders of magnitude, enabling metabolic MRI. Even though hyperpolarization has shown clear value in clinical studies, the complexity, cost and slowness of current equipment limits its widespread use. Here, a polarization procedure of [1‐13C]pyruvate based on parahydrogen‐induced polarization by side‐arm hydrogenation (PHIP‐SAH) in an automated polarizer is demonstrated. It is benchmarked in a study with 48 animals against a commercial dissolution dynamic nuclear polarization (d‐DNP) device. Purified, concentrated (≈70–160 mM) and highly hyperpolarized (≈18%) solutions of pyruvate are obtained at physiological pH for volumes up to 2 mL within 85 s in an automated process. The safety profile, image quality, as well as the quantitative perfusion and lactate‐to‐pyruvate ratios, are equivalent for PHIP and d‐DNP, rendering PHIP a viable alternative to established hyperpolarization techniques.
Funder
Deutsche Forschungsgemeinschaft
Bundesministerium für Bildung und Forschung
Subject
General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)
Cited by
3 articles.
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