Affiliation:
1. Department of Rheumatology and Immunology Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing 210096 P. R. China
2. Wenzhou Institute University of Chinese Academy of Sciences Wenzhou Zhejiang 325000 P. R. China
3. Oujiang Laboratory School of Pharmaceutical Sciences Wenzhou Medical University Wenzhou Zhejiang 325035 P. R. China
Abstract
AbstractFibrous scaffolds have shown their advantages in tissue engineering, such as peripheral nerve regeneration, while most of the existing fiber‐shaped scaffolds are with simple structures, and the in vitro performance for nerve regeneration lacks systematic analysis. Here, novel nerve‐on‐a‐chip derived biomimicking microfibers for peripheral nerve regeneration are presented. The microfibers with controllable core–shell structures and functionalities are generated through capillary microfluidic devices. By integrating these microfibers into a multitrack‐architectured chip, and coculturing them with nerve cells as well as gradient bioactive elements, the nerve‐on‐a‐chip with the capabilities of systematically assessing the performances of nerve fiber formation in the hollow microfibers at in vitro level is constructed. Based on a rat sciatic nerve injury model, the rapid promotion ability is demonstrated of optimized microfibers in nerve regeneration and function recovery in vivo, which implies the credibility of the nerve‐on‐a‐chip on biomimicking microfibers evaluation for peripheral nerve regeneration. Thus, it is convinced that the organ‐on‐a‐chip will undoubtedly open up a new chapter in evaluating biological scaffolds for in vivo tissue engineering.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Nanjing Medical Science and Technique Development Foundation
Shenzhen Fundamental Research Program
Subject
General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)
Cited by
10 articles.
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