A Bioinspired Flexible Sensor for Electrochemical Probing of Dynamic Redox Disequilibrium in Cancer Cells

Author:

Zeng Zhongyuan1,Wang Jian12,Zhao Shuang34,Zhang Yuchan1,Fan Jingchuan1,Wu Hui1,Chen Jiajia1,Zhang Zaikuan5,Meng Zexuan1,Yang Lu1,Wang Renzhi6,Zhang Bo6,Wang Guixue34,Li Chen‐Zhong6ORCID,Zang Guangchao124

Affiliation:

1. Institute of Life Science and Laboratory of Tissue and Cell Biology Lab Teaching & Management Center Chongqing Medical University Chongqing 400016 P. R. China

2. Department of Pathophysiology Chongqing Medical University Chongqing 400016 P. R. China

3. Key Laboratory for Biorheological Science and Technology of Ministry of Education State and Local Joint Engineering Laboratory for Vascular Implants Bioengineering College of Chongqing University Chongqing 400030 P. R. China

4. Jinfeng Laboratory Chongqing 401329 P. R. China

5. The M.O.E. Key Laboratory of Laboratory Medical Diagnostics The College of Laboratory Medicine Chongqing Medical University Chongqing 400016 P. R. China

6. Bioelectronics and Biosensors Center School of Medicine Chinese University of Hong Kong Shenzhen 2001 Longxiang Avenue, Longgang District Shenzhen 518172 P. R. China

Abstract

AbstractMalignant tumors pose a serious risk to human health. Ascorbic acid (AA) has potential for tumor therapy; however, the mechanism underlying the ability of AA to selectively kill tumor cells remains unclear. AA can cause redox disequilibrium in tumor cells, resulting in the release of abundant reactive oxygen species, represented by hydrogen peroxide (H2O2). Therefore, the detection of H2O2 changes can provide insight into the selective killing mechanism of AA against tumor cells. In this work, inspired by the ion‐exchange mechanism in coral formation, a flexible H2O2 sensor (PtNFs/CoPi@CC) is constructed to monitor the dynamics of H2O2 in the cell microenvironment, which exhibits excellent sensitivity and spatiotemporal resolution. Moreover, the findings suggest that dehydroascorbic acid (DHA), the oxidation product of AA, is highly possible the substance that actually acts on tumor cells in AA therapy. Additionally, the intracellular redox disequilibrium and H2O2 release caused by DHA are positively correlated with the abundance and activity of glucose transporter 1 (GLUT1). In conclusion, this work has revealed the potential mechanism underlying the ability of AA to selectively kill tumor cells through the construction and use of PtNFs/CoPi@CC. The findings provide new insights into the clinical application of AA.

Funder

Natural Science Foundation of Chongqing

Chongqing Municipal Education Commission Foundation

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

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