Metabolism‐Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53‐Mutant Colon Cancer

Author:

Tang Meng12345,Xu Hui1,Huang Hongyan6,Kuang Hao17,Wang Chenxi4,Li Qinqin2,Zhang Xin8,Ge Yizhong23,Song Mengmeng23,Zhang Xi23,Wang Ziwen23,Ma Chaobing4,Kang Jinlin1,Zhang Wanfang1,Wang You1,Zhang Bo6,Zhang Xiaowei23,Chen Yongbing23,Cong Minghua5,Melino Gerry9,Wang Xiaobin10,Zhou Fuxiang1,Sun Qiang4,Shi Hanping23ORCID

Affiliation:

1. Department of Radiation and Medical Oncology Hubei Key Laboratory of Tumor Biological Behaviors Hubei Clinical Cancer Study Center Zhongnan Hospital of Wuhan University Wuhan 430071 China

2. Department of Gastrointestinal Surgery/ Department of Clinical Nutrition Beijing Shijitan Hospital Capital Medical University Beijing 10038 China

3. Key Laboratory of Cancer FSMP for State Market Regulation Beijing 100038 China

4. Laboratory of Cell Engineering, Institute of Biotechnology Research Unit of Cell Death Mechanism, 2021RU008 Chinese Academy of Medical Science 20 Dongda Street Beijing 100071 China

5. Comprehensive Oncology Department National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China

6. Department of Oncology Beijing Shijitan Hospital Capital Medical University Beijing 10038 China

7. Department of Radiation Oncology Sichuan Cancer Hospital Chengdu 610041 China

8. Department of Pediatric Hematology and Oncology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai 200092 China

9. Department of Experimental Medicine TOR University of Rome“Tor Vergata” Rome 50‐00133 Italy

10. Department of Population Family and Reproductive Health Johns Hopkins University Bloomberg School of Public Health; and Department of Pediatrics Johns Hopkins University School of Medicine Baltimore Maryland 21287 USA

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

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