Inhibiting the IRE1 <i>α</i> Axis of the Unfolded Protein Response Enhances the Antitumor Effect of AZD1775 in <i>TP53</i> Mutant Ovarian Cancer-Reference-Cited by-同舟云学术

Inhibiting the IRE1 α Axis of the Unfolded Protein Response Enhances the Antitumor Effect of AZD1775 in TP53 Mutant Ovarian Cancer

Published:2022-05-26 Issue:21 Volume:9 Page:2105469
ISSN:2198-3844
Container-title:Advanced Science
language:en
Short-container-title:Advanced Science

Author:

Xiao Rourou¹²³,You Lixin¹²³,Zhang Li¹²³,Guo Xichen⁴,Guo Ensong¹²³,Zhao Faming⁴,Yang Bin¹²³,Li Xi¹²³,Fu Yu¹²³,Lu Funian¹²³,Wang Zizhuo¹²³,Liu Chen¹²³,Peng Wenju¹²³,Li Wenting¹²³,Yang Xiaohang¹²³,Dou Yingyu¹²³,Liu Jingbo¹²³,Wang Wei¹²³,Qin Tianyu¹²³,Cui Yaoyuan¹²³,Zhang Xiaoxiao⁵,Li Fuxia⁶,Jin Yang⁷,Zeng Qingping⁸,Wang Beibei¹²³,Mills Gordon B.⁹,Chen Gang¹²³,Sheng Xia⁴,Sun Chaoyang¹²³^ORCID

Affiliation:

1. National Clinical Research Center for Gynecology and Obstetrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

2. Cancer Biology Research Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

3. Department of Gynecology and Obstetrics, Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

4. Key Laboratory of Environment and Health Ministry of Education & Ministry of Environmental Protection and State Key Laboratory of Environmental Health (Incubation) School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

5. Department of Obstetrics and Gynecology The First Affiliated Hospital of Zhengzhou University Zheng Zhou 450052 China

6. Department of gynecology First Affiliated Hospital Shihezi University School of Medicine Shihezi Xinjiang 832000 P. R. China

7. Department of Biosciences University of Oslo Oslo 0371 Norway

8. Fosun Orinove Inc. Unit 211, Building A4, 218 Xinhu Street Suzhou 215000 China

9. Department of Cell Development and Cancer Biology Knight Cancer Institute Oregon Health and Sciences University Portland OR 97201 USA

Publisher

Wiley

Subject

General Physics and Astronomy,General Engineering,Biochemistry, Genetics and Molecular Biology (miscellaneous),General Materials Science,General Chemical Engineering,Medicine (miscellaneous)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202105469

Reference44 articles.

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2. Suppression of the p53- or pRB-mediated G1 checkpoint is required for E2F-induced S-phase entry

3. Targeting WEE1 Kinase in Cancer

4. Strategic development of AZD1775, a Wee1 kinase inhibitor, for cancer therapy

5. Targeting the DNA Damage Response in Cancer

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